Breakthrough device promises to detect glucose without needles

Recently, one small device has been drawing significant attention for tackling that problem in a very different way.

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Blood sugar levels can rise or fall quickly. When changes go unnoticed, the risks increase, from long-term organ damage to sudden hypoglycemia.

At the same time, glucose tracking has surged among people without diabetes. As GLP-1 medications gain popularity, many people now track their blood sugar to understand how food affects their bodies. The need for simpler tools keeps growing.

Even Apple has spent years trying to bring no-prick glucose tracking to wearables. Despite heavy investment, the feature has yet to arrive.

The breath-based design is intended to reduce how often users need finger-prick blood tests, while providing early alerts for glucose-related changes.

The device is named after the inventor's grandson, Isaac, who was diagnosed with type 1 diabetes at just two years old. The inventor, Bud Wilcox, wanted to reduce the number of painful finger pricks his grandson faced each day. That personal motivation led to years of collaboration with scientists, designers and engineers. Research and development included work with Indiana University, under the direction of Dr. M. Agarwal. The goal was simple but ambitious. Alert families to blood sugar events earlier while reducing the physical and emotional toll of constant testing.

This matters because people with diabetes can become disoriented or incapacitated during hypoglycemic events. Early alerts give caregivers or family members a chance to step in. A single charge lasts all day and supports multiple breath tests. The device comes with a USB-C charging cradle and cable.

According to PreEvnt, isaac is being developed for:

It may also appeal to people focused on metabolic health. As mentioned, the device is still undergoing development and FDA review and is not yet for sale in the U.S. The companion app will launch on iOS and Android closer to availability.

PreEvnt first introduced isaac publicly at CES 2025. Later that year, the device entered active human clinical trials. Those studies compare isaac's breath-based alerts with traditional blood glucose monitoring methods. Trials began with adolescents who have type 1 diabetes and later expanded to adults with type 2 diabetes. The company is now working toward regulatory review with the U.S. Food and Drug Administration. Because this technology is new, PreEvnt is pursuing a de novo pathway, which allows devices to be evaluated while standards are still being defined. According to the company, regulators have shown strong interest as the data continues to come in.

Isaac does not claim to replace medical-grade glucose meters. The device is being developed to supplement existing monitoring methods by offering breath-based alerts tied to glucose-related changes.

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